We have located links that may give you full text access.
Journal Article
Research Support, Non-U.S. Gov't
Metabolic tumor volumes by [18F]-fluorodeoxyglucose PET/CT correlate with occult metastasis in oral squamous cell carcinoma of the tongue.
Annals of Surgical Oncology 2009 November
BACKGROUND: To investigate the correlation between pretreatment metabolic tumor volume (MTV) as determined by [(18)F]-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) and occult metastasis (OM) in oral squamous cell carcinoma (OSCC) of the tongue.
METHODS: Forty-three clinically node-negative (cN0) OSCC patients, diagnosed by preoperative workups (biopsy, physical examination, CT, and PET/CT) were enrolled. All patients had undergone primary tumor resections and elective neck dissections. MTVs were measured for tumors showing standardized uptake value (SUV) of >2.5 by an automated contouring program. Pretreatment variables (age, sex, clinical T stage, maximal SUV [SUV(max)] and MTV) and posttreatment variables (pathologic T stage, depth of invasion, lymphovascular invasion, pathologic tumor volume, and histological differentiation) were analyzed to identify their correlation with OM.
RESULTS: Twelve (27.9%) of 43 patients were found to have OM in pathologic specimen of neck dissections. A cutoff of 6.0 ml for the MTV was determined to be the most discriminative value for predicting OM. By univariate analysis, the patients with an MTV of >6.0 ml had significantly higher number of occult metastases than those with an MTV of
CONCLUSIONS: MTV as determined by PET/CT demonstrated a statistically significant correlation with OM in patients with cN0 OSCC of the tongue.
METHODS: Forty-three clinically node-negative (cN0) OSCC patients, diagnosed by preoperative workups (biopsy, physical examination, CT, and PET/CT) were enrolled. All patients had undergone primary tumor resections and elective neck dissections. MTVs were measured for tumors showing standardized uptake value (SUV) of >2.5 by an automated contouring program. Pretreatment variables (age, sex, clinical T stage, maximal SUV [SUV(max)] and MTV) and posttreatment variables (pathologic T stage, depth of invasion, lymphovascular invasion, pathologic tumor volume, and histological differentiation) were analyzed to identify their correlation with OM.
RESULTS: Twelve (27.9%) of 43 patients were found to have OM in pathologic specimen of neck dissections. A cutoff of 6.0 ml for the MTV was determined to be the most discriminative value for predicting OM. By univariate analysis, the patients with an MTV of >6.0 ml had significantly higher number of occult metastases than those with an MTV of
CONCLUSIONS: MTV as determined by PET/CT demonstrated a statistically significant correlation with OM in patients with cN0 OSCC of the tongue.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app