The novel histone deacetylase inhibitors metacept-1 and metacept-3 potently increase HIV-1 transcription in latently infected cells

Miranda Shehu-Xhilaga, David Rhodes, Fiona Wightman, Hong B Liu, Ajantha Solomon, Suha Saleh, Anthony E Dear, Paul U Cameron, Sharon R Lewin
AIDS 2009 September 24, 23 (15): 2047-50
We investigated the ability of several novel class I histone deacetylase inhibitors to activate HIV-1 transcription in latently infected cell lines. Oxamflatin, metacept-1 and metacept-3 induced high levels of HIV-1 transcription in latently infected T cell and monocytic cells lines, were potent inhibitors of histone deacetylase activity and caused preferential cell death in transcriptionally active cells. Although these compounds had potent in-vitro activity, their cytotoxicity may limit their use in patients.

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