Combination therapy with clindamycin and rifampicin for hidradenitis suppurativa: a series of 116 consecutive patients

G Gener, F Canoui-Poitrine, J E Revuz, O Faye, F Poli, G Gabison, F Pouget, C Viallette, P Wolkenstein, S Bastuji-Garin
Dermatology: International Journal for Clinical and Investigative Dermatology 2009, 219 (2): 148-54

BACKGROUND: Antibiotics are frequently used to treat hidradenitis suppurativa (HS); however, few data on their efficacy are available.

OBJECTIVE: To evaluate the efficacy of a combination of systemic clindamycin (300 mg twice daily) and rifampicin (600 mg daily) in the treatment of patients with severe HS.

METHODS: Patients (n = 116) who received this combination were studied retrospectively. The main outcome measure was the severity of the disease, assessed by the Sartorius score, before and after 10 weeks of treatment.

RESULTS: The Sartorius score dramatically improved at the end of treatment (median = 29, interquartile range = 14.5, vs. median = 14.5, interquartile range = 11; p < 0.001), as did other parameters of severity as well as the quality of life score. Eight patients (6.9%) stopped the treatment because of side effects.

CONCLUSION: The combination of clindamycin and rifampicin is effective in the treatment of severe HS.

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