HLA-G 3' UTR haplotypes and HIV vertical transmission

Ludovica Segat, Eulalia Catamo, Annalisa Fabris, Lara Padovan, Marcello Morgutti, Sergio Crovella
AIDS 2009 September 10, 23 (14): 1916-8
We evaluated the possible association of human leukocyte antigen-G (HLA-G) 3777G>C and 14-bp deletion/insertion (D/I) polymorphisms haplotypes and combined genotypes with perinatal HIV transmission in Brazilian children. The 3777G>C polymorphism alone has no effect on HIV vertical transmission but, when linked with the D allele, exerts a positive role in the protection. Indeed, we identified the DC HLA-G haplotype as significantly associated with a protective effect towards HIV vertical transmission.

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