Xenobiotic kidney organogenesis: a new avenue for renal transplantation

Takashi Yokoo, Tetsuya Kawamura
Journal of Nephrology 2009, 22 (3): 312-7
Currently many efforts are being made to apply regenerative medicine to clinical renal diseases. It has been suggested that some renal diseases which maintain renal structure can be treated by infusion of stem cells isolated from the bone marrow or adult kidney. However such cell-based therapy cannot be applied to the treatment of chronic renal disease, in which renal structure, including the kidney scaffold, is totally disrupted. Therefore, absolute kidney regeneration is needed to rebuild a whole functional kidney de novo and eliminate the requirement for dialysis. However, due to the anatomical complexity of the kidney and the need for communication between each cell to fulfill renal function, the kidney has been labeled as the most difficult organ to regenerate. Only a small number of groups are investigating the potential for reconstructing an organized and functional kidney structure, and, among them, we are using the developing xenoembryo as an organ factory for this purpose. Here we review the challenges faced in developing a whole functional kidney de novo and discuss the obstacles which must be overcome before clinical use is possible.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"