[Postprandial changes of blood lipid after ordinary Chinese diet and the influencing factors thereof].

OBJECTIVE: To investigate the postprandial changes of blood lipid after ordinary Chinese diet and the influencing factors thereof.

METHODS: Peripheral venous blood samples were collected from 88 patients, 72 males and 16 females, aged (65 +/- 12), 53 with hypertension, 35 with coronary heart diseases, and 27 with diabetes, while fasting and 4 h after breakfast and lunch to measure the levels of lipoproteins, including total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A (ApoA), ApoB, lipoprotein (Lp) (a), oxidized LDL (ox-LDL). Homeostasis model assessment insulin resistance index (HOMA-IR) was calculated. Weight, height, waist circumference, and hip circumference were examined, and body mass index (BMI) and waist/hip ratio (WHR) were calculated.

RESULTS: The TG level after breakfast was (2.79 +/- 0.19) mmol/L, significantly higher than the fasting level by 49.5% [(1.94 +/- 0.13) mmol/L, P < 0.05]. The TG level after lunch was (3.08 +/- 0.26) mmol/L, significantly higher than the fasting level by 58.8% [(1.94 +/- 0.13) mmol/L, P < 0.05]. The ox-LDL after breakfast was (430 +/- 21) microg/L, significantly higher than the fasting level by 32.6% [(324 +/- 14) microg/L, P < 0.05] and the ox-LDL level after lunch was (448 +/- 17) microg/L, significantly higher than the fasting level by 38.1% [(324 +/- 14) microg/L, P < 0.05]. The fasting insulin level was (62 +/- 4) pmol/L, and the HOMA-IR was (15.27 +/- 1.08). The fasting insulin level was positively correlated with the fasting and postprandial TG levels (all P < 0.01). The IR index was positively correlated with the fasting TG and TG after breakfast (both P < 0.05). Fasting insulin and HOMA-IR were negatively correlated with the fasting and postprandial HDL-C levels (all P < 0.05), and positively correlated with the fasting and postprandial TC/HDL-C levels (all P < 0.05). BMI and WHR were negatively correlated with the fasting and postprandial HDL-C (both P < 0.01). BMI was positively correlated with fasting and postprandial TG (both P < 0.05). The insulin level, HOMA-IR, and BMI were negatively correlated with LPL (r = -0.232 - 0.297, P < 0.05). LPL were positively correlated with fasting and postprandial HDL-C levels (r = 0.37, 0.31, 0.35, all P < 0.01).

CONCLUSION: The TG and ox-LDL levels significantly increased postprandially. The postprandial blood lipid levels are significantly correlated with the fasting blood lipids.