JOURNAL ARTICLE

[Clinical-pathological characteristics and survival of triple negative breast cancer]

Qi He, Jie Wang, Yu-guo Shao, Xiao-yun Zhou, Zhi-min Shao
Zhonghua Yi Xue za Zhi [Chinese medical journal] 2009 February 3, 89 (4): 243-7
19552840

OBJECTIVE: To investigate the clinical-pathological characteristics of triple negative breast cancer.

METHODS: The clinical-pathological characteristics of 690 breast cancer patients, all females, 127 being estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor (HER)-2 triple negative, were analyzed.

RESULTS: The expression rate of P53, a tumor suppressor gene, of the triple negative breast cancer patients was 71.42% (75/127), significantly higher than that of the non-triple negative breast cancer patients (42.56%, P < 0.01), and the expression rate of epidermal growth factor receptor (EGFR) of the triple negative breast cancer was 59.74%, significantly higher than that of the non-triple negative breast cancer patients (22.06%, P = 0.013). The local lymph node metastasis rate of the triple negative breast cancer was 22.22%, significantly higher than that of the non-triple negative breast cancer patients (2.70%, P = 0.048). The 5-year overall survival (OS) rate and 10-year OS rate of he triple negative breast cancer patients were 79.67% and 63.15% respectively, both significantly lower than those of the non-triple negative breast cancer patients (88.59% and 83.28% respectively, both P = 0.001). The 5-year and 10-year disease free survival (DFS) rates of the triple negative breast cancer patients were 77.94% and 62.87% respectively, both significantly lower than those of the non-triple negative breast cancer patients (83.82% and 82.53% respectively, both P = 0.011), especially that within 36 months.

CONCLUSION: Triple negative breast cancer is related with P53 and EGFR expression, and tends to metastasize to local lympho-nodes. The survival rate of triple negative breast cancer patients is significantly lower than that of non-triple negative breast cancer.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
19552840
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"