We have located links that may give you full text access.
English Abstract
Journal Article
[Treatment of cancer of unknown primary, today and future].
Cancer of unknown primary(CUP)is a malignant disease with metastases such as lymph nodes, lung or liver metastasis, and without an identified primary site. CUP constitutes 5% of all human malignant diseases. CUPs are divided into two sub-groups, favorable and unfavorable, based on their clinical output. In the unfavorable group, platinumbased CUPs or those combined with taxane regimens have been examined in phase II trials and practically conducted with high frequency. However, no standard regimens have thus far been established. Chemotherapy based on the primary site is not applicable for the treatment of CUP. It is very difficult to apply any regimens without information on the primary sites. To resolve this problem, molecular diagnostic technologies using a gene expression profiling platform to identify the primary site of CUP are now applied. Primary site-dependent chemotherapy could be conducted in accordance with the result of the molecular diagnosis of the primary site. On the other hand, the idea that the unfavorable group is an independent entity of malignancy is supported. The unfavorable CUPs might have a common molecular mechanism. Identification of the underlying mechanism that is specific to the unfavorable CUP may be a clue to develop a novel treatment for CUP.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app