COMPARATIVE STUDY
JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Add like
Add dislike
Add to saved papers

Comparison of survival between patients with hereditary non polyposis colorectal cancer (HNPCC) and sporadic colorectal cancer.

BACKGROUND: Hereditary non polyposis colorectal cancer (HNPCC) appears to have a better prognosis than sporadic cancer. In the present study we evaluated the clinical outcome of HNPCC patients with respect to that of patients with colorectal cancer recorded in a population-based cancer registry. Aim of our study was to examine survival rates in Iranian HNPCC patients with colorectal cancer and compare them with survival rates of sporadic cases arising from the general population.

PATIENTS AND METHODS: The population studied consists of 121 individuals including 61 patients with sporadic colorectal cancer and 60 patients with HNPCC who were followed-up between 2003 and 2008 in Taleghani hospital Tehran. The subjects with HNPCC were screened according to Amsterdam criteria II and Bethesda Guidelines. All those with sporadic cancer had no familial history of colorectal cancer. Observed survival was estimated using the Kaplan-Meier method and compared with log rank test. Multivariate analysis was performed using the Cox regression analysis.

RESULTS: In the HNPCC group, 85.0% showed tumors in colon, vs. 68.9% in the sporadic cancer group. The 5-year survival was 82.5% in the HNPCC study group compared with only 56.4% in the general population group (P= 0.044). The age distribution at diagnosis of sporadic patients was significantly higher than HNPCC patients (mean 50.1 years vs 44.3 years P= 0.008). The hazard ratio for sporadic for tumor location was 3.233 (95% CI 1.123-9.307) compared with the HNPCC group (P= 0.030).

CONCLUSION: Our findings corroborate the results of previous study which showed overall survival of colorectal cancer in patients with HNPCC is better than sporadic CRC patients.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app