JOURNAL ARTICLE
MULTICENTER STUDY

Self administered cognitive screening test (TYM) for detection of Alzheimer's disease: cross sectional study

Jeremy Brown, George Pengas, Kate Dawson, Lucy A Brown, Philip Clatworthy
BMJ: British Medical Journal 2009 June 9, 338: b2030
19509424

OBJECTIVE: To evaluate a cognitive test, the TYM ("test your memory"), in the detection of Alzheimer's disease.

DESIGN: Cross sectional study.

SETTING: Outpatient departments in three hospitals, including a memory clinic.

PARTICIPANTS: 540 control participants aged 18-95 and 139 patients attending a memory clinic with dementia/amnestic mild cognitive impairment.

INTERVENTION: Cognitive test designed to use minimal operator time and to be suitable for non-specialist use.

MAIN OUTCOME MEASURES: Performance of normal controls on the TYM. Performance of patients with Alzheimer's disease on the TYM compared with age matched controls. Validation of the TYM with two standard tests (the mini-mental state examination (MMSE) and the Addenbrooke's cognitive examination-revised (ACE-R)). Sensitivity and specificity of the TYM in the detection of Alzheimer's disease.

RESULTS: Control participants completed the TYM with an average score of 47/50. Patients with Alzheimer's disease scored an average of 33/50. The TYM score shows excellent correlation with the two standard tests. A score of <or=42/50 had a sensitivity of 93% and specificity of 86% in the diagnosis of Alzheimer's disease. The TYM was more sensitive in detection of Alzheimer's disease than the mini-mental examination, detecting 93% of patients compared with 52% for the mini-mental state exxamination. The negative and positive predictive values of the TYM with the cut off of <or=42 were 99% and 42% with a prevalence of Alzheimer's disease of 10%. Thirty one patients with non-Alzheimer dementias scored an average of 39/50.

CONCLUSIONS: The TYM can be completed quickly and accurately by normal controls. It is a powerful and valid screening test for the detection of Alzheimer's disease.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
19509424
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"