JOURNAL ARTICLE

Green tea consumption and gastric cancer in Japanese: a pooled analysis of six cohort studies

M Inoue, S Sasazuki, K Wakai, T Suzuki, K Matsuo, T Shimazu, I Tsuji, K Tanaka, T Mizoue, C Nagata, A Tamakoshi, N Sawada, S Tsugane et al.
Gut 2009, 58 (10): 1323-32
19505880

BACKGROUND: Previous experimental studies have suggested many possible anti-cancer mechanisms for green tea, but epidemiological evidence for the effect of green tea consumption on gastric cancer risk is conflicting.

OBJECTIVE: To examine the association between green tea consumption and gastric cancer.

METHODS: We analysed original data from six cohort studies that measured green tea consumption using validated questionnaires at baseline. Hazard ratios (HRs) in the individual studies were calculated, with adjustment for a common set of variables, and combined using a random-effects model.

RESULTS: During 2 285 968 person-years of follow-up for a total of 219 080 subjects, 3577 cases of gastric cancer were identified. Compared with those drinking <1 cup/day, no significant risk reduction for gastric cancer was observed with increased green tea consumption in men, even in stratified analyses by smoking status and subsite. In women, however, a significantly decreased risk was observed for those with consumption of > or =5 cups/day (multivariate-adjusted pooled HR = 0.79, 95% confidence interval (CI) = 0.65 to 0.96). This decrease was also significant for the distal subsite (HR = 0.70, 95% CI = 0.50 to 0.96). In contrast, a lack of association for proximal gastric cancer was consistently seen in both men and women.

CONCLUSIONS: Green tea may decrease the risk of distal gastric cancer in women.

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