Two new neo-clerodane diterpenoid alkaloids from Scutellaria barbata with cytotoxic activities

Sheng-Jun Dai, Wei-Bing Peng, Li Shen, De-Wu Zhang, Yan Ren
Journal of Asian Natural Products Research 2009, 11 (5): 451-6
Two new neo-clerodane diterpenoid alkaloids, scutebarbatine O (1) and 6-O-nicotinoylscutebarbatine G (2), were isolated from the whole plant of Scutellaria barbata. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR analyses. In vitro, compounds 1 and 2 showed cytotoxic activities against three human tumor cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and with IC(50) values in the range of 2.1-5.7 microM.

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