Conformationally constrained aromatic oligoamide foldamers with supersecondary structure motifs

Hai-Yu Hu, Jun-Feng Xiang, Chuan-Feng Chen
Organic & Biomolecular Chemistry 2009 June 21, 7 (12): 2534-9
The design, synthesis, and structural studies of aromatic foldamers based on oligo(phenanthroline dicarboxamide)s that displayed supersecondary structure motifs have been described. Governed by a combined conformational restriction, the foldamers adopted well defined and compact 3D structures, which have been validated by UV/Vis, NMR spectra, and X-ray crystal analysis. The results presented here would offer a useful route for the de novo design of aromatic oligoamide foldamers with distinctive structural architectures.

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