Dynamic of pneumococcal nasopharyngeal carriage in children with acute otitis media following PCV7 introduction in France

R Cohen, C Levy, E Bonnet, S Grondin, V Desvignes, A Lecuyer, B Fritzell, E Varon
Vaccine 2010 August 23, 28 (37): 6114-21
To determine whether the use of seven valent pneumococcal conjugate vaccine (PCV7) caused a shift in the Streptococcus pneumoniae serotypes distribution and whether it modified the resistance to antibiotics, 3291 nasopharyngeal swabs were obtained between 2001 and 2006, from children aged 6-24 months with acute otitis media. Following the implementation of PCV7, we observed a slight reduction in the overall pneumococcal carriage, a marked decrease of vaccine serotypes, an increase in non-vaccine serotypes carriage and a reduction in the carriage of penicillin non-susceptible strains. Most of the serotype 19A replacement was related to the clonal expansion of ST276 which was found to be the predominant ST among penicillin non-susceptible isolates.

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