JOURNAL ARTICLE

Cognitive-enhancing activity of loganin isolated from Cornus officinalis in scopolamine-induced amnesic mice

Ki Yong Lee, Sang Hyun Sung, Seung Hyun Kim, Young Pyo Jang, Tae Hwan Oh, Young Choong Kim
Archives of Pharmacal Research 2009, 32 (5): 677-83
19471881
We examined anti-amnesic activity of the methanolic extract of Cornus officinalis fruits (COT) and a major constituent, loganin using scopolamine-induced (1 mg/kg body weight, s.c.) amnesic mice with both passive avoidance and the Morris water maze tests. Oral treatment of mice with COT (100 mg/kg body weight) and loganin (1 and 2 mg/kg body weight) significantly mitigated scopolamine-induced memory deficits in passive avoidance test. In the Morris water maze test, oral treatment of loganin significantly ameliorated scopolamine-induced memory deficits showing the formation of long-term and/or short-term spatial memory. Moreover, loganin (2 mg/kg body weight) significantly inhibited acetylcholinesterase activity by as much as 45% of control in the mouse hippocampus. These results indicate that loganin may exert antiamnesic activity in in vivo through acetylcholinesterase inhibition.

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