Regulation of human immunodeficiency virus-1 latency and its reactivation

E Verdin
Bulletin et Mémoires de L'Académie Royale de Médecine de Belgique 2008, 163 (6): 355-64; discussion 364-5
Treatment of human immunodeficiency virus (HIV) infection with highly active antiretroviral therapy (HAART) has become highly effective. However the persistence of a small population of infected cells containing transcriptionally silent but re-activatable HIV proviruses prevents complete elimination of the infection. Here, we review recent progress in our understanding of the molecular mechanisms underlying HIV proviral latency and highlight experimental therapies designed to eliminate the latent population.

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