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JOURNAL ARTICLE
Ablation of klotho and premature aging: is 1,25-dihydroxyvitamin D the key middleman?
Kidney International 2009 June
The reversal of soft-tissue abnormalities and prolonged lifespan observed in klotho(-/-) mice following genetic inactivation of 1alpha-hydroxylase underscores the pathophysiological role of 1,25-dihydroxyvitamin D in mediating some of the premature aging-like features observed in klotho(-/-) mice.
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