COMPARATIVE STUDY
JOURNAL ARTICLE

Nonspecific interstitial pneumonia associated with collagen vascular disease: analysis of CT features to distinguish the various types

Tadahisa Daimon, Takeshi Johkoh, Osamu Honda, Hiromitsu Sumikawa, Kazuya Ichikado, Yasuhiro Kondoh, Hiroyuki Taniguchi, Kiminori Fujimoto, Masahiro Yanagawa, Atsuo Inoue, Noriyuki Tomiyama, Hironobu Nakamura, Yukihiko Sugiyama
Internal Medicine 2009, 48 (10): 753-61
19443969

OBJECTIVE: The purpose of this study was to analyze the CT findings of interstitial lung diseases that are associated with collagen vascular disease (CVD), with particular attention to nonspecific interstitial pneumonia (NSIP), and to examine whether it is possible to predict the clinical diagnosis of CVDs based on the CT findings alone.

METHODS: CT scans of 49 patients with NSIP associated with CVD (15 males, 34 females; mean age, 55+/-10 years; age range, 25-76 years) were included in this retrospective study. All patients underwent a surgical biopsy. The clinical diagnosis comprised rheumatoid arthritis (RA) (n=15), systemic sclerosis (SSc) (n=8), polymyositis and dermatomyositis (PM/DM) (n=18), Sjögren's syndrome (SjS) (n=4), and mixed connective tissue disease (MCTD) (n=4). Each CT was reviewed by two independent observers who made a clinical diagnosis based on the CT findings alone.

RESULTS: The observers made a correct diagnosis for 22 (45%) of the 49 patients. A correct diagnosis was made for: RA in 7 (47%) of 15 patients; SSc in 3 (38%) of 8 patients; PM/DM in 11 (61%) of 18 patients; SjS in 1 (25%) of 4 patients. None of the 4 MCTD cases was diagnosed.

CONCLUSION: It is difficult to make a correct clinical diagnosis of the various types of CVDs based solely on CT findings. However, it is probable to make a reasonably accurate clinical diagnosis in cases that show the typical CT findings, especially for PM/DM patients.

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