The protective effect of Zizyphus jujube fruit on carbon tetrachloride-induced hepatic injury in mice by anti-oxidative activities.

AIM OF THE STUDY: The study was aimed to investigate the protective effect against hepatic injury induced by CCl(4) for the ethanolic extract of FZJ.

MATERIALS AND METHODS: The alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were detected as biomarker in blood of hepatic injury. Product of lipid peroxidation (MDA), activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), and reduced glutathione (GSH) contents were evaluated for oxidative stress in hepatic injury. Moreover, histopathological observation was assayed at the degree of hepatic injury.

RESULTS: After administrated the FZJ, the dose of 200mg/kg significantly decreased ALT and AST, and attenuated histopathology of hepatic injury, and ameliorated the oxidative stress in hepatic tissue. Partly assayed indexes were ameliorated after administrated FZJ at the dose of 100mg/kg.

CONCLUSION: These results indicated that hepatic protective effects of FZJ were very relevant to modulate the oxidative stress in hepatic injury.