JOURNAL ARTICLE
REVIEW

Systematical approach of formulation and process development using roller compaction

Yue Teng, Zhihui Qiu, Hong Wen
European Journal of Pharmaceutics and Biopharmaceutics 2009, 73 (2): 219-29
19406236
The roller compaction process has gained heightened interest in the pharmaceutical industry. In this review, common excipients and equipment used for dry granulation are described. Roller compaction process parameters and their impact on the critical quality attributes of the final product, as well as evaluation methods for roller compaction product such as ribbons and granules, are discussed. Overall, a systematical approach of formulation and process development has been proposed for excipient selection, critical process parameter identification, and necessary tests.

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