Modulation of conduction velocity by nonmyocytes in the low coupling regime

Vincent Jacquemet, Craig S Henriquez
IEEE Transactions on Bio-medical Engineering 2009, 56 (3): 893-6
This paper explores the conditions under which nonmyocytes, when electrically coupled to myocytes, act as a passive load during the depolarization phase. Using theoretical arguments and numerical simulations in a tissue incorporating fibroblasts, the passive load approximation is shown to be accurate at low coupling conductances (< 2 nS). In this case, the effect on conduction velocity can be expressed as a function of the elevation in resting potential and the coupling only.

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