Molecular basis for cancer chemoprevention by green tea polyphenol EGCG

Hirofumi Tachibana
Forum of Nutrition 2009, 61: 156-69
For the past two decades, many researchers have been investigating the potential cancer-preventive and therapeutic effects of green tea. (-)-Epigallocatechin-3-O-gallate (EGCG) has been shown to be the most active and major polyphenolic compound from green tea. The mechanisms of action of EGCG have been extensively investigated. However, the mechanisms for the cancer-preventive activity of EGCG are not completely characterized and many features remain to be elucidated. Recently, we have identified the 67-kDa laminin receptor (67LR) as a cell surface EGCG receptor that confers EGCG responsiveness to many cancer cells at physiological concentrations. This article reviews some of the reported mechanisms and possible targets for the action of EGCG. We especially focus on the current understanding of the signaling pathway for physiologically relevant EGCG through the 67LR for cancer prevention. Our data shed new light on the molecular basis for the cancer-preventive activity of EGCG in vivo and helps in the design of new strategies to prevent cancer.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"