JOURNAL ARTICLE

A dual DTI approach to analyzing white matter in children with dyslexia

John C Carter, Diane C Lanham, Laurie E Cutting, Amy M Clements-Stephens, Xuejing Chen, Muhamed Hadzipasic, Joon Kim, Martha B Denckla, Walter E Kaufmann
Psychiatry Research 2009 June 30, 172 (3): 215-9
19346108
Using voxel-based (VBA) and region-of-interest (ROI) diffusion tensor imaging (DTI) analyses, we examined white matter (WM) organization in seven children with dyslexia and six age-matched controls. Both methods demonstrated reduced fractional anisotropy (FA) in the left superior longitudinal fasciculus (SLF) and abnormal orientation in the right SLF in dyslexics. Application of this complementary dual DTI approach to dyslexia, which included novel analyses of fiber orientation, demonstrates its usefulness for analyzing mild and complex WM abnormalities.

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