Typhlitis during second-line chemotherapy with pemetrexed in non-small cell lung cancer (NSCLC): A case report

Marcello Tiseo, Francesco Gelsomino, Marco Bartolotti, Matteo Pesenti Barili, Andrea Ardizzoni
Lung Cancer: Journal of the International Association for the Study of Lung Cancer 2009, 65 (2): 251-3
Neutropenic enterocolitis, or typhlitis, is an unusual acute complication of chemotherapy-induced neutropenia, characterized by inflammatory process involving colon and/or small bowel that may progress to necrosis, haemorrhage, perforation and septicaemia. Typhlitis is usually seen in the setting of severe chemotherapy-induced neutropenia for acute leukaemia. Nevertheless, it is increasingly recognized as a complication of therapy in solid tumors. We present a case of typhlitis in a patient with advanced non-small cell lung cancer (NSCLC) who received pemetrexed, as second-line chemotherapy treatment.

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