[Acute recurrent hemolytic anemia as the first manifestation of Wilson's disease: Report of a case].

A El Khattabi, H Seddik, J Fatihi, H Salaheddine, M Badaoui, T Amézyane, F Mahassine, V Ohayon

Transfusion Clinique et Biologique : Journal de la Société Française de Transfusion Sanguine 2009 March

INTRODUCTION: The liver and central nervous system are the usual targets of Wilson's disease, an inherited disorder of copper metabolism. Severe hemolytic anemia is an unusual complication of Wilson's disease.

EXEGESIS: We report a case of Wilson's disease revealed by acute intravascular repeating hemolytic anemia associated with liver failure. The initially negative etiologic investigation was directed by occurred of liver failure. The genetic study allowed to discover an other similar case. The evolution was favourable under treatment with zinc sulfate and penicillamine.

DISCUSSION: Diagnosis of Wilson's disease must be considered in case of acute hemolytic anemia associated with liver failure in young adults.

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