White matter alterations in male patients with obsessive-compulsive disorder

Tae Hyon Ha, Do-Hyung Kang, Jun Sung Park, Joon Hwan Jang, Wi Hoon Jung, Jung-Seok Choi, Ji-Young Park, Myung Hun Jung, Chi-Hoon Choi, Jong-Min Lee, Kyooseob Ha, Jun Soo Kwon
Neuroreport 2009 May 6, 20 (7): 735-9
To investigate white matter abnormalities in patients with obsessive-compulsive disorder and to clarify the relationship between discrete white matter alterations and obsessive-compulsive symptom dimensions, the fractional anisotropy obtained from 25 male patients and 25 matched normal controls were analyzed. The patients had a significantly lower fractional anisotropy in the left anterior cingulate white matter than the controls. When stratified by clinical symptom dimensions, patients with a predominant aggressive/checking symptom dimension exhibited a significantly lower fractional anisotropy in the left anterior cingulate white matter, whereas patients with a predominant contamination/cleaning symptom dimension showed a significantly higher fractional anisotropy in the bilateral prefrontal white matter. Our findings provide evidence that obsessive-compulsive disorder may be a heterogeneous disease with distinct white matter changes.

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