JOURNAL ARTICLE

Use of monoclonal antibodies as an effective strategy for treatment of ciguatera poisoning

Masayuki Inoue, Nayoung Lee, Takeshi Tsumuraya, Ikuo Fujii, Masahiro Hirama
Toxicon: Official Journal of the International Society on Toxinology 2009, 53 (7): 802-5
19254735
Ciguatera is a global food poisoning caused by the consumption of fish that have accumulated sodium channel activator toxins, ciguatoxins. At present, most diagnosed cases of ciguatera are treated with symptomatic and supportive remedies, and no specific therapy has been devised. Here we report that ciguatoxin CTX3C can be effectively neutralized in vitro and in vivo by simultaneous use of two anti-ciguatoxin monoclonal antibodies, providing the first rational approach toward directly preventing and treating ciguatera.

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