COMPARATIVE STUDY
JOURNAL ARTICLE

The safety and efficacy of continuous transcranial duplex Doppler monitoring of middle cerebral artery occlusion in acute stroke patients: comparison of TCDD and thrombolysis in MCA recanalization

Daniel Sanák, Roman Herzig, David Skoloudík, David Horák, Jana Zapletalová, Martin Köcher, Petr Kanovský
Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging 2010, 20 (1): 58-63
19226343

BACKGROUND AND PURPOSE: Assess the safety and efficacy of the continuous transcranial duplex Doppler (TCDD) monitoring of middle cerebral artery (MCA) (M1-2) occlusion in acute ischemic stroke (IS) patients and compare TCDD to intra-arterial thrombolysis (IAT) and intravenous thrombolysis (IVT).

METHODS: Forty consecutive acute IS patients were analyzed. Standard IVT was performed within 3 hours since stroke onset in 20 patients; between 3 and 6 hours continual 60 minute TCDD monitoring of occluded MCA using 2-MHz probe was performed in 10 patients and IAT in 10 patients. Neurological deficit was evaluated using the National Institutes of Health Stroke Scale and clinical outcome using modified Rankin Scale. The incidence of symptomatic intracerebral hemorrhage (sICH), clinical outcomes, and recanalization rates were compared among TCDD, IVT, and IAT. Analysis of variance, Kruskal-Wallis, and chi(2) tests were used for statistical evaluation.

RESULTS: Incidence of sICH was 0% in TCDD group, 5% in IVT, and 20% in IAT (P= .198). Good 90-day clinical outcome (mRS 0-2) was achieved in 70% of TCDD patients (P= .570); recanalization after TCDD was found in 60% of patients (IVT 45%, IAT 70%) (P= .185).

CONCLUSION: Continual TCDD monitoring might be safe and potentially beneficial in treatment of MCA occlusion.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
19226343
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"