A randomized, double-blinded, controlled trial comparing parenteral normal saline with and without dextrose on the course of labor in nulliparas

Vineet K Shrivastava, Thomas J Garite, Sheri M Jenkins, Lisa Saul, Pamela Rumney, Christine Preslicka, Kenneth Chan
American Journal of Obstetrics and Gynecology 2009, 200 (4): 379.e1-6

OBJECTIVE: The objective of the study was to compare intravenous normal saline with and without dextrose on the course of labor in nulliparae.

STUDY DESIGN: In a double-blinded, controlled trial, term, nulliparae with singletons in active labor were randomized into 1 of 3 groups receiving either normal saline (NS), NS with 5% dextrose (D5NS), or NS with 10% dextrose (D10NS) at 125 mL/h. The primary outcome was total length of labor from onset of study fluid in vaginally delivered subjects. Maternal and neonatal outcomes were also analyzed.

RESULTS: Of 300 subjects enrolled, 289 met inclusion criteria and completed the study. In vaginally delivered subjects, significant differences were noted in the second stage (P = .01) and total length of labor (P = .02). No significant differences were observed in the cesarean section rates between the groups (P = .21). No differences were noted in maternal or neonatal secondary outcomes.

CONCLUSION: Administration of a dextrose solution, regardless of concentration, was associated with a shortened labor course in term vaginally delivered nulliparae subjects in active labor.

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