Protective effects of telmisartan on ischemia/reperfusion injury of rat ovary: biochemical and histopathologic evaluation

Yakup Kumtepe, Fehmi Odabasoglu, Mehmet Karaca, Beyzagul Polat, Mesut Bünyamin Halici, Osman Nuri Keles, Zuhal Altunkaynak, Fatma Gocer
Fertility and Sterility 2010 March 1, 93 (4): 1299-307

OBJECTIVE: To evaluate the effects of telmisartan as an antioxidant and for its tissue protective properties and to study the biochemical and histopathologic changes in experimental ischemia and ischemia/reperfusion injuries in rat ovaries.

DESIGN: Experimental study.

SETTING: Experimental surgery laboratory in a university department.

ANIMAL(S): Forty-eight female adult rats.

INTERVENTION(S): I: sham operation; II: bilateral ovarian ischemia; III: 3 h ischemia + 3 h reperfusion. IV and V: Rats were administered 10 and 20 mg/kg doses of telmisartan, respectively, before 0.5 h of ischemia, and then ovarian ischemia was applied; after 3 h of ischemia, the ovaries were removed. VI and VII: 3 h ovarian ischemia was applied; 2.5 h after the induction of ischemia, rats were administered the same doses of telmisartan; at the end of 3 h of ischemia, the ovaries were removed and a 3 h reperfusion followed.

MAIN OUTCOME MEASURE(S): Superoxide dismutase, inducible nitric oxide synthase, and myeloperoxidase activity in rat ovarian tissue; and histopathologic changes in the ovarian tissue of the rats.

RESULT(S): Ischemia and ischemia-reperfusion increased the inducible nitric oxide synthase and myeloperoxidase activity while decreasing the super oxide dismutase activity significantly in comparison with the sham group. Before ischemia and ischemia/reperfusion, telmisartan reversed the trend in inducible nitric oxide synthase activities and the level of myeloperoxidase.

CONCLUSION(S): telmisartan is effective in reversing tissue damage induced by ischemia/reperfusion in ovaries.

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