JOURNAL ARTICLE

Superparamagnetic iron oxide nanoparticles coated with mannan for macrophage targeting

Mi Kyong Yoo, In Young Park, In Yong Kim, In Kyu Park, Jin-Sook Kwon, Hwan-Jeong Jeong, Yong Yeon Jeong, Chong Su Cho
Journal of Nanoscience and Nanotechnology 2008, 8 (10): 5196-202
19198420
To develop the functionalized superparamagnetic iron oxide nanoparticles (SPIONs) demonstrating the capacities to be delivered in antigen presenting cells specifically and to be dispersed in physiological environment stably, the nanoparticle surface was coated with mannan that induces receptor-mediated endocytosis. Mannan is a water-soluble polysaccharide having high content of D-mannose residues to be recognized by mannose receptors on immunate macrophages. Mannan-coated SPIONs (mannan-SPIONs) were prepared by traditional coprecipitation method, followed by a thermochemical treatment and post-coating with mannan solution. Poly(vinyl alcohol)-coated SPIONs (PVA-SPIONs) were also prepared as a control. Upon characterization, mannan-SPIONs were proven to be suitable for MR imaging due to small size, excellent stability in ferrofluid, and low cytotoxicity. In addition mannan-SPIONs exhibited enhanced targeted delivery efficiency to macrophages than PVA-SPIONs in vitro and in vivo. Therefore, mannan as a coating material not only prevented the aggregation of SPIONs in physiological medium but also provided a capacity to be delivered in antigen presenting cells specifically, suggesting of the potential utility of mannan-SPIONs as a macrophage-targeting MRI contrast agent.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
19198420
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"