MicroRNA expression and its implications for the diagnosis and therapeutic strategies of breast cancer

Ming Shi, Ning Guo
Cancer Treatment Reviews 2009, 35 (4): 328-34
Alterations in microRNA (miRNA) expression have been associated with tumor suppression or tumorigenesis, metastasis and poor prognosis in human breast cancer. Deregulation of miRNAs is emerging as a major aspect of cancer etiology because their capacity to direct the translation and stability of targeted transcripts can dramatically influence cellular physiology. Some miRNAs were considered to be associated with molecular subtypes of breast cancer and correlated with specific breast cancer clinicopathological factors, such as HER2, estrogen and progesterone receptor level, tumor stage, vascular invasion, or proliferation index. The expression level of miRNAs as suppressors, which can inhibit the expression of tumor promoting genes, is frequently down-regulated in breast cancer. Multiple lines of evidence also demonstrated the involvement of specific miRNAs as oncogenes in breast tumorigenesis. Some miRNAs have been considered to have potential clinical applications as a novel biomarker for breast cancer diagnosis and prognostic factor. Exploitation of the therapeutic potential of RNA interference will be an important task and achieved through the further understanding of the mechanisms of gene regulation by miRNAs.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"