Cortical oscillatory power changes during auditory oddball task revealed by spatially filtered magnetoencephalography

Ryouhei Ishii, Leonides Canuet, Anthony Herdman, Atsuko Gunji, Masao Iwase, Hidetoshi Takahashi, Takayuki Nakahachi, Masayuki Hirata, Stephen E Robinson, Christo Pantev, Masatoshi Takeda
Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology 2009, 120 (3): 497-504

OBJECTIVE: To investigate the neural sources and associated changes in oscillatory activity involved in auditory attention and memory updating processing using spatially filtered magnetoencephalography.

METHODS: We recorded magnetic responses during an auditory oddball task in 12 normal subjects. Synthetic aperture magnetometry (SAM)-permutation analysis was used to visualize the multiple brain regions associated with event-related magnetic fields (ERFs), and event-related oscillations during target detection processing.

RESULTS: SAM-permutation results showed the topographical distribution of N1m over the bilateral primary auditory cortex. Post-stimulus delta (1.5-4 Hz) activity sources, likely related to the P300 slow-waveform, were distributed over the right frontocentral and parietal regions. Source locations of theta (4-8 Hz) and alpha (8-13 Hz) event-related synchronization (ERS) were identified over the dorsolateral and medial prefrontal cortex. We visualized bilateral central-Rolandic suppresions for mu (8-15 Hz), beta (15-30 Hz), and low-gamma (30-60 Hz) activities, more dominant in the hemisphere contralateral to the moving hand (button-pressing in response to target stimuli).

CONCLUSIONS: Prefrontal theta and alpha ERS, and frontocentral-parietal delta ERS are functionally engaged in auditory attention and memory updating process.

SIGNIFICANCE: Spatially filtered MEG is valuable for detection and source localization of task-related changes in the ongoing oscillatory activity during oddball tasks.

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