JOURNAL ARTICLE

Diagnostic value of platelet indices in children with leukemia

Suleimman A Alsweedan, Abdallah Al-Shurman, Al-Sheyyab Mahmoud
Journal of Pediatric Hematology/oncology 2008, 30 (12): 953-5
19131790
The purpose of this study was to investigate whether platelet indices [mean platelet volume (MPV) and platelet distribution width (PDW)] could serve as diagnostic tools for screening or as surrogate marker for follow-up in children with leukemia. Blood samples were obtained from 47 patients with leukemia at diagnosis before chemotherapy (mean age: 67 mo; 30 males and 17 females) and from 47 healthy controls (mean age: 59 mo; 27 males and 20 females). We measured the blood platelet indices using an automated counter. MPV was higher in the leukemia group, but it was not statistically significant. However, PDW was significantly lower (P<0.001) in leukemia group. There was no significant difference in the MPV or PDW in patients with acute lymphoblastic leukemia versus acute myeloblastic leukemia. In conclusion, we found no significant difference in the MPV between the 2 groups. PDW proposed as indicators of certain pathologic conditions and it seems possible to use PDW as screening. However, platelet indices (MPV and PDW) cannot be used as indicator to discriminate between the subtypes of leukemia in children. The potential role of platelet indices in leukemia remains to be investigated by a multi-institutional level to verify the possible clinical significance of this finding.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
19131790
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"