COMPARATIVE STUDY
JOURNAL ARTICLE
RANDOMIZED CONTROLLED TRIAL

Tranexamic acid reduces blood loss in off-pump coronary artery bypass surgery

Reza Jalaeian Taghaddomi, Asadollah Mirzaee, Alireza Sharifian Attar, Abbas Shirdel
Journal of Cardiothoracic and Vascular Anesthesia 2009, 23 (3): 312-5
19103500

OBJECTIVE: This study was designed to evaluate the hemostatic effect of tranexamic acid in off-pump coronary artery bypass surgery.

DESIGN: A prospective, randomized, double-blind, placebo-controlled study.

SETTING: The Department of Anesthesiology and Cardiac Surgery, Medical Sciences University.

PARTICIPANTS: One hundred eight patients undergoing off-pump coronary artery bypass surgery were enrolled into the study. Eight patients were withdrawn, and 100 patients were divided into 2 groups.

INTERVENTIONS: Fifty patients received tranexamic acid (bolus 1 g before skin incision and followed by maintenance dose of 400 mg/h during surgery), and 50 patients received saline.

MEASUREMENT AND MAIN RESULTS: Hematologic parameters, volume of blood loss, blood transfusion, and other clinical data were recorded throughout the perioperative period. Twenty-four-hour postoperative blood loss was significantly less in the tranexamic acid group compared with the control group (471 +/- 182 v 844 +/- 303). Patients in the tranexamic acid group received significantly less allogeneic blood (8 v 31 units).

CONCLUSION: Bleeding and hemorrhagic complications and the consequent need for allogeneic transfusion are still major problems after off-pump coronary artery bypass surgery. Tranexamic acid appears to be effective in reducing postoperative bleeding and the need for allogeneic blood products.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
19103500
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"