JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Add like
Add dislike
Add to saved papers

Association of waist circumference, traditional cardiovascular risk factors, and stromal-derived factor-1 in adolescents.

Pediatric Diabetes 2009 August
BACKGROUND: Overweight and the metabolic syndrome (MS) represent dramatically increasing problems in children and adolescents. Waist circumference (WC) is an important factor to determine MS. So far, WC is a predictor of blood pressure, high-density lipoprotein (HDL), insulin concentration, and visceral fat in adolescents. We investigated whether WC and body mass index standard deviation score (BMI-SDS) are predictors of adiponectin, stromal-derived factor (SDF-1), and soluble E-selectin (sE-selectin) as parameters for beginning insulin resistance and endothelial damage.

METHODS: Seventy-nine male Caucasian adolescents were studied, aged 13-17 yr. Thirty-eight (48%) of them had a WC above 90th age percentile. All participants were enrolled in one consultation, recording various parameters and collecting one blood sample.

RESULTS: Differences in systolic blood pressure, HDL, high sensitive C-reactive protein, and hemoglobin A1c could be found between groups above or below the 90th WC percentile. Linear regression analysis revealed that WC and BMI-SDS predict traditional risk factors, as well as reduced adiponectin, lower SDF-1, and higher sE-selectin levels. Multiple linear regression analyses show that SDF-1 is in closest correlation to WC and BMI-SDS.

CONCLUSIONS: WC and BMI-SDS predict various alterations of traditional and new cardiovascular risk factors. SDF-1 might be a new marker for diagnosis of obesity-related diseases and help understand pathophysiologic mechanisms.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app