JOURNAL ARTICLE

Extensions of the penalized spline of propensity prediction method of imputation

Guangyu Zhang, Roderick Little
Biometrics 2009, 65 (3): 911-8
19053998
Little and An (2004, Statistica Sinica 14, 949-968) proposed a penalized spline of propensity prediction (PSPP) method of imputation of missing values that yields robust model-based inference under the missing at random assumption. The propensity score for a missing variable is estimated and a regression model is fitted that includes the spline of the estimated logit propensity score as a covariate. The predicted unconditional mean of the missing variable has a double robustness (DR) property under misspecification of the imputation model. We show that a simplified version of PSPP, which does not center other regressors prior to including them in the prediction model, also has the DR property. We also propose two extensions of PSPP, namely, stratified PSPP and bivariate PSPP, that extend the DR property to inferences about conditional means. These extended PSPP methods are compared with the PSPP method and simple alternatives in a simulation study and applied to an online weight loss study conducted by Kaiser Permanente.

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