We have located links that may give you full text access.
JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
In vitro pharmacological evaluation of three Barleria species.
Journal of Ethnopharmacology 2009 January 22
ETHNOPHARMACOLOGICAL RELEVANCE: Various parts of Barleria prionitis L. (Acanthaceae) are used in traditional medicine to treat infection-related ailments. A comparison of their activities and knowledge of their mechanisms of action are important for drug development and conservation.
AIMS OF THE STUDY: This study investigated the antibacterial effects and underlying mechanisms of action of the anti-inflammatory activities of different parts of three Barleria species of South African origin.
MATERIALS AND METHODS: Crude extracts of different parts of three Barleria species were investigated in vitro for their biological activity. Antibacterial activity was evaluated using the micro-dilution assay against two Gram-positive and two Gram-negative bacteria. Anti-inflammatory activity was evaluated using the cyclooxygenase COX-1 and COX-2 assays.
RESULTS: All the extracts showed broad-spectrum antibacterial activity with minimum inhibitory concentrations ranging from 0.059 to 6.25mg/ml. Twelve out of 21 crude extracts evaluated showed good activity (>70%) in the COX-1 assay while 10 extracts showed good activity in the COX-2 assay. All the petroleum ether extracts (except B. prionitis stem) exhibited good inhibition of prostaglandin synthesis in COX-1.
CONCLUSION: The results demonstrated the therapeutic potential of these plants as antibacterial and anti-inflammatory agents. Their anti-inflammatory properties are mediated by the inhibition of the cyclooxygenase enzymes.
AIMS OF THE STUDY: This study investigated the antibacterial effects and underlying mechanisms of action of the anti-inflammatory activities of different parts of three Barleria species of South African origin.
MATERIALS AND METHODS: Crude extracts of different parts of three Barleria species were investigated in vitro for their biological activity. Antibacterial activity was evaluated using the micro-dilution assay against two Gram-positive and two Gram-negative bacteria. Anti-inflammatory activity was evaluated using the cyclooxygenase COX-1 and COX-2 assays.
RESULTS: All the extracts showed broad-spectrum antibacterial activity with minimum inhibitory concentrations ranging from 0.059 to 6.25mg/ml. Twelve out of 21 crude extracts evaluated showed good activity (>70%) in the COX-1 assay while 10 extracts showed good activity in the COX-2 assay. All the petroleum ether extracts (except B. prionitis stem) exhibited good inhibition of prostaglandin synthesis in COX-1.
CONCLUSION: The results demonstrated the therapeutic potential of these plants as antibacterial and anti-inflammatory agents. Their anti-inflammatory properties are mediated by the inhibition of the cyclooxygenase enzymes.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app