JOURNAL ARTICLE

[Characterization of rabies virus phosphoprotein in high prevalence provinces of China]

Xiao-Guang Wang, Xiao-Yan Tao, Hao Li, Miao Song, Jia-Liang Du, Qiang Zhang, Zhao-Jun Mo, Kai-Jiao Zhou, Hong Zhang, De-Fang Dai, Ding-Ming Wang, Jin-Zhu Zhou, Qing Tang, Guo-Dong Liang
Chinese Journal of Experimental and Clinical Virology 2008, 22 (3): 165-7
19031691

OBJECTIVE: Characterization of rabies virus phosphoprotein through analyzation of genetic variations about rabies virus phosphoproteins in high-incidence regions in China.

METHODS: The nucleotide sequence of the P gene of Guangxi, Guizhou and Hunan provinces positive sample's were sequenced, and the P region's similarity and phylogenetic analyses were completed by using softer wares.

RESULTS: The similarity of P region's nucleotide sequence is 82.1%-100%, while, the similarity of amino acid sequence is 87.5%-100%. A little variation in phosphoprotein cannot influence its biological functions.

CONCLUSION: All rabies viruses isolated from Guangxi, Guizhou and Hunan provinces belong to genotype 1 and share same phylogenesis and same genome characteristic; Virus distribution presents unique Characterization; Some virus isolates from Hunan province and Thailand may come from the same virus.

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