Dissemination of OXA-23-producing and carbapenem-resistant Acinetobacter baumannii in a University Hospital in Tunisia

Wejdene Mansour, Laurent Poirel, Dalia Bettaieb, Olfa Bouallegue, Noureddine Boujaafar, Patrice Nordmann
Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease 2008, 14 (4): 289-92
Ninety-nine carbapenem-resistant Acinetobacter baumannii isolates were obtained from patients hospitalized between October 2005 and January 2007 at the University Hospital Sahloul, Sousse, Tunisia. Thirteen of those isolates produced the carbapenem-hydrolyzing oxacillinase OXA-23. All the OXA-23-positive isolates were clonally related, and the bla(OXA-23) gene was found to be chromosomally located and associated with an upstream-located insertion sequence ISAba1. This study further highlights the worldwide emergence of OXA-23-producing A. baumannii isolates.

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