JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Add like
Add dislike
Add to saved papers

Toll-Like Receptor expressions in porcine alveolar macrophages and Dendritic Cells in responding to poly IC stimulation and porcine reproductive and respiratory syndrome virus (PRRSV) infection.

Antigen-presenting cells play critical roles in recognizing, presenting and processing antigens and consequently induce adequate immune response for defending infections. The immature DCs (imDCs) and mature DCs (mDCs) were obtained from in vitro differentiation of bone marrow haematopoietic cells. Results showed that poly IC stimulation down-regulated the expressions of TLR7 and TLR8 in alveolar macrophages (AMs) and imDCs. The release of IL-12 was inhibited from imDCs and mDCs in response to poly IC. Porcine reproductive and respiratory syndrome virus (PRRSV)-infection inhibited TLR3 and TLR7 expressions in AMs and imDCs at 6h post-infection (PI); both of expressions were then restored at 24h PI in both types of cells while they exhibited up-regulated IL-10 and IL-12 expression at 24h PI. Hence, the differential TLR expression patterns in porcine AMs and DCs in discrimination of the imitated viral dsRNA or PRRSV infection may determine their cytokine expressions and thus affect the resulting immune responses.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app