Prenatal factors and the development of asthma

Rajesh Kumar
Current Opinion in Pediatrics 2008, 20 (6): 682-7

PURPOSE OF REVIEW: There is increasing evidence that both prenatal and perinatal events influence both allergic diseases and early-life respiratory morbidity.

RECENT FINDINGS: Studies in the last year have suggested that in-utero exposures including tobacco smoke exposure, dietary exposures including vitamin D, and prenatal infection and exposure to microbial products may modulate both atopy and respiratory disease. There have been studies revealing gene x environment interactions between inflammatory pathway genes and in-utero smoke exposure. There have also been studies which have revealed that prenatal exposure to endotoxin may be protective. On the other hand, a recent study also suggested that chorioamnionitis may increase the risk of recurrent wheezing in combination with preterm birth. Finally, two separate large cohort studies evaluated maternal diet in pregnancy and suggested that vitamin D levels may be protective against asthma and wheezing.

SUMMARY: There is epidemiological evidence for multiple prenatal factors impacting early-life respiratory morbidity. The mechanisms of these factors need further investigation and may act via various pathways which include effects on lung development, allergic and nonallergic inflammation, and airway remodeling. It remains to be determined if some of these early-life factors which predispose to wheezing will all translate into increased risk of asthma.


You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Available on the App Store

Available on the Play Store
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"