JOURNAL ARTICLE

Hyperkeratosis lenticularis perstans (Flegel's disease) - successful treatment with topical corticosteroids

Heleen Sterneberg-Vos, Arienne M W van Marion, Jorge Frank, Pamela Poblete-Gutierrez
International Journal of Dermatology 2008, 47 Suppl 1: 38-41
18986485
Flegel's disease, also known as hyperkeratosis lenticularis perstans, is a rare skin disease characterized by small, red-brown, hyperkeratotic, papules that are usually located on the lower extremities. The diagnosis is based on the clinical appearance in association with the typical histologic features of orthohyperkeratosis and a subepidermal band-like infiltrate. Treatment is difficult and rarely fully effective. We report on a woman with Flegel's disease who responded to a topical corticosteroid therapy with betamethasone dipropionate.

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