[Subclinical hypothyroidism]

Robert Krysiak, Bogdan Marek, Bogusław Okopień
Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego 2008, 61 (4): 139-45
Subclinical hypothyroidism, defined by elevated serum levels of thyroid stimulating hormone (TSH) with normal levels of free thyroid hormones, belongs to the most common disorders encountered in an endocrine office practice. It is assumed that elevated TSH levels in patients with subclinical hypothyroidism do not reflect pituitary compensation to maintain euthyroidism but probably represents a state of mild tissue hypothyroidism. Some patients with this condition experience subtle hypothyroid symptoms and have mild abnormalities of serum lipoproteins that may provoke atherosclerosis and cardiac dysfunction. Subclinical hypothyroidism is also associated with the risk of progression to overt hypothyroidism and with the risk of neuropsychiatric effects. For these reasons, subclinical hypothyroidism should be screened more carefully in the community. There is insufficient evidence that treatment ofsubclinical hypothyroidism is beneficial. Thyroxine therapy should be given if the serum TSH level is higher than 10 mIU/L but for lower TSH values, the decision for therapy should be individualized. This article reviews the epidemiology, etiopathogenesis, clinical presentation, diagnosis, and management of subclinical hypothyroidism. Based on the principles of evidence-based medicine, we provide some screening and treatment recommendations.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"