JOURNAL ARTICLE
MULTICENTER STUDY

Impact of intravenous loop diuretics on outcomes of patients hospitalized with acute decompensated heart failure: insights from the ADHERE registry

W Franklin Peacock, Maria Rosa Costanzo, Teresa De Marco, Margarita Lopatin, Janet Wynne, Roger M Mills, Charles L Emerman
Cardiology 2009, 113 (1): 12-9
18931492
The optimal use of diuretics in decompensated heart failure remains uncertain. We analyzed data from the ADHERE registry to look at the impact of diuretic dosing. 62,866 patients receiving <160 mg and 19,674 patients > or =160 mg of furosemide were analyzed. The patients receiving the lower doses had a lower risk for in-hospital mortality, ICU stay, prolonged hospitalization, or adverse renal effects. These findings suggest that future studies should evaluate strategies for minimizing exposure to high doses of diuretics.

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