DNA repair by the MRN complex: break it to make it

Roland Kanaar, Claire Wyman
Cell 2008 October 3, 135 (1): 14-6
Genomic instability in ataxia telangiectasia-like disorder and Nijmegen breakage syndrome is due to disruption of the Mre11-Rad50-Nbs1 complex. Buis et al. (2008) and Williams et al. (2008) now reveal the importance of the nuclease activity of Mre11 for mammalian genome maintenance and present a molecular view of its active site.

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