Create a free QxMD account to receive personalized paper recommendations, relevant to your practice.

COMMENT

JOURNAL ARTICLE

DNA repair by the MRN complex: break it to make it

Roland Kanaar, Claire Wyman

Cell 2008 October 3, 135 (1): 14-6

Genomic instability in ataxia telangiectasia-like disorder and Nijmegen breakage syndrome is due to disruption of the Mre11-Rad50-Nbs1 complex. Buis et al. (2008) and Williams et al. (2008) now reveal the importance of the nuclease activity of Mre11 for mammalian genome maintenance and present a molecular view of its active site.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Breast cancer risk is associated with the genes encoding the DNA double-strand break repair Mre11/Rad50/Nbs1 complex. Huan-Ming Hsu, Hui-Chun Wang, Sou-Tong Chen, Giu-Cheng Hsu, Chen-Yang Shen, Jyh-Cherng Yu Cancer Epidemiology, Biomarkers & Prevention 2007, 16 (10): 2024-32

The importance of making ends meet: mutations in genes and altered expression of proteins of the MRN complex and cancer. Agnieszka Dzikiewicz-Krawczyk Mutation Research 2008, 659 (3): 262-73

Structural and functional analysis of Mre11-3. L Matthew Arthur, Karin Gustausson, Karl-Peter Hopfner, Christian T Carson, Travis H Stracker, Annette Karcher, Diana Felton, Matthew D Weitzman, John Tainer, James P Carney Nucleic Acids Research 2004, 32 (6): 1886-93

The Mre11/Rad50/Nbs1 complex plays an important role in the prevention of DNA rereplication in mammalian cells. Alan Yueh-Luen Lee, Enbo Liu, Xiaohua Wu Journal of Biological Chemistry 2007 November 2, 282 (44): 32243-55

DNA double-strand breaks come into focus. Karl-Peter Hopfner Cell 2009 October 2, 139 (1): 25-7

Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation. Jeffrey Buis, Yipin Wu, Yibin Deng, Jennifer Leddon, Gerwin Westfield, Mark Eckersdorff, Joann M Sekiguchi, Sandy Chang, David O Ferguson Cell 2008 October 3, 135 (1): 85-96

Double functions for the Mre11 complex during DNA double-strand break repair and replication. Valérie Borde, Jennifer Cobb International Journal of Biochemistry & Cell Biology 2009, 41 (6): 1249-53

Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene. Jirina Bartkova, Johanna Tommiska, Lenka Oplustilova, Kirsimari Aaltonen, Anitta Tamminen, Tuomas Heikkinen, Martin Mistrik, Kristiina Aittomäki, Carl Blomqvist, Päivi Heikkilä, Jiri Lukas, Heli Nevanlinna, Jiri Bartek Molecular Oncology 2008, 2 (4): 296-316

The MRE11 complex: starting from the ends. Travis H Stracker, John H J Petrini Nature Reviews. Molecular Cell Biology 2011, 12 (2): 90-103

MRE11 complex links RECQ5 helicase to sites of DNA damage. Lu Zheng, Radhakrishnan Kanagaraj, Boris Mihaljevic, Sybille Schwendener, Alessandro A Sartori, Bertran Gerrits, Igor Shevelev, Pavel Janscak Nucleic Acids Research 2009, 37 (8): 2645-57

Make the most of Read.
Download the mobile app.

Want full text access to this paper?

Use Read by QxMD to access full text via your institution or open access sources.

Read also provides personalized recommendations to keep you up to date in your field.

Existing User

New to Read

DNA repair by the MRN complex: break it to make it

Discussion

Related Papers

Want full text access to this paper?

Save your favorite articles in one place with a free QxMD account.

Read

Search Tips