Prevalence and associated risk factors of non-alcoholic fatty liver disease in hospitalized patients

Corina Radu, Mircea Grigorescu, Dana Crisan, Monica Lupsor, Diana Constantin, Liliana Dina
Journal of Gastrointestinal and Liver Diseases: JGLD 2008, 17 (3): 255-60

BACKGROUND AND AIM: Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS) have become important health issues in many countries. There is increasing interest in ultrasound-diagnosed NAFLD. The aim of the study was to evaluate the prevalence of NAFLD in hospitalized patients and to determine the metabolic features of ultrasound-diagnosed patients.

METHODS: A number of 3,005 hospitalized patients were prospectively assessed. Subjects were submitted to a standard interview and a chart review was made to note anthropometric (BMI and waist circumference), biochemical and abdominal ultrasonography parameters. MS was evaluated according to IDF criteria. Logistic regression analysis was used to identify independent factors associated with ultrasound-diagnosed NAFLD.

RESULTS: The prevalence of NAFLD in the enrolled subjects was 20%. Patients with NAFLD had higher values of BMI and waist circumference. MS was present in 61.09 % of cases with NAFLD. At least one risk factor was observed in 88.41%, and in 14.07% of patients all 5 criteria were fulfilled. The odds ratios of the metabolic disorders in subjects with NAFLD compared with those without NAFLD were higher in the overweight and obese group than in the normal-weight group. Central obesity, hypertriglyceridemia, and elevated blood pressure (for total and the overweight group) were independently associated with NAFLD.

CONCLUSION: The prevalence of ultrasound NAFLD in hospitalized patients was similar to the general population. NAFLD was closely associated with metabolic disorders.

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