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Assembly system of direct modified superparamagnetic iron oxide nanoparticles for target-specific MRI contrast agents.

Kazuo Tanaka, Narufumi Kitamura, Masahito Morita, Toshiro Inubushi, Yoshiki Chujo
Bioorganic & Medicinal Chemistry Letters 2008 October 16
We report the direct modification of SPIOs with a biomolecule and the target-specific assembly system of these modified SPIOs for using MRI contrast agents. The transverse relaxation rate of the aqueous solutions containing the modified SPIOs was altered by the dispersion state.

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