Evidence for internal filtration in the Genius system, performing slow low efficient daily dialysis in the intensive care unit

Sunny Eloot, Wim Van Biesen, Annemieke Dhondt, Erik Billiet, Pascal Verdonck, Raymond Vanholder
Blood Purification 2008, 26 (5): 460-7

BACKGROUND: Since most intensive care units (ICUs) have no access to high-quality water, the Genius system, using ultrapure water and high-flux dialyzers, might be used during slow low efficient daily dialysis (SLEDD). To get an idea about convective removal, internal filtration (IF) was calculated and compared to other modalities.

METHODS: Validated with in vivo measurements, IF was calculated for 8 h Genius SLEDD and 4 h Genius standard dialysis with high-flux dialyzers, and for 8 h SLEDD and 4 h both with standard dialysis machines and low-flux as well as high-flux dialyzers.

RESULTS: In Genius SLEDD (FX80), IF was 2.36 l (hematocrit [Hct] 30%) and 3.37 l (Hct 40%). About the same amount of IF was found for the different dialysis modalities, except when using low-flux dialyzers, where no IF occurred.

CONCLUSION: The Genius system allows the implementation of high-flux dialysis with ultrapure dialysate, and can be run in a SLEDD mode in the ICU.

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