JOURNAL ARTICLE

Gastric cancer histology: clinicopathologic characteristics and prognostic value

Joong-Min Park, You-Jin Jang, Jong-Han Kim, Sung-Soo Park, Seong-Heum Park, Seung-Joo Kim, Young-Jae Mok, Chong-Suk Kim
Journal of Surgical Oncology 2008 December 1, 98 (7): 520-5
18802956

BACKGROUND AND OBJECTIVES: Gastric cancer can be divided into two major histologic categories, that is, differentiated and undifferentiated types. In the present study, we sought to clarify the prognoses and clinicopathologic characteristics of signet ring cell carcinoma and mucinous carcinoma, both of which are mucin-producing tumors of the undifferentiated type.

METHODS: We retrospectively reviewed medical records of 2,275 patients who underwent gastric resection. Cases were divided into four histologic groups: differentiated carcinoma (well differentiated and moderately differentiated, WMD), poorly differentiated (PD), signet ring cell carcinoma (SRC), and mucinous carcinoma (MC).

RESULTS: The overall cumulative 5-year survival rates for patients were 67% for WMD, 54% for PD, 65% for SRC, and 48% for MC. The outcome of SRC was similar to that of WMD, whereas that of MC was similar to that of PD. Stage-stratified analysis revealed that histologic type was not statistically related to survival in patients with stage I, II, or III. On the other hand, histologic type in patients with stage IV disease was found to be significantly associated with survival.

CONCLUSIONS: Histologic classifications of mucin-producing gastric cancers should separately be considered from other histologic types.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
18802956
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.